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Originals Although peptic ulcer (PU) is counted as one of the various work-related diseases, little is
known about the risk factors other than health habits. The authors used data from the Japan
Workers stress and Health survey-an 18-month follow-up study-to ascertain whether
psychosocial factors play any role in the development of PU in the working population.
The subjects were 9.204 men, working at various occupations and firms aged 30 through
59 years, who had no prior history of PU at baseline. People with extremely severe life
event stress had an increased risk of PU compared with those who had no such
experience. An increased risk was found when the frequency of late night work was 10-12
times a month compared with none. Five items related to perceived work overload-too
much responsibility poor relations with superior, understaffing, excess of evening /holiday
business meetings, and physically too tiring -were each positively associated with PU. Life
event stress frequency of rate night work, and perceived work overload were all
independently associated with the onset of PU after controlling for age and smoking.
These results provide evidence that psychosocial factors play an important role in the
development of PU.
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