| Keywords |
o-dichlorobenzene, 3,4- and 4,5-dichlorocatechols,
2,3- and 3,4-dichlorophenols, Urinary metabolites, Biological
monitoring |
| Abstract |
Relations between Exposure to o-Dichlorobenzene
and Concentrations of Urinary Metabolites: Shinji Kumagai, et
al. Department of Occupational Health, Osaka Prefectural Institute
of Public Health-The present study aimed to examine the relation
between exposure to airborne o-dichlorobenzene (o-DCB) and concentrations
of four urinary metabolites, i.e., 3,4-dichlorocatechol (3,4-DCC),
4,5-dichlorocatechol (4,5-DCC), 2,3-dichlorophenol (2,3-DCP)
and 3,4-dichlorophenol (3,4-DCP). Subjects were ten male workers
exposed to o-DCB in synthesizing intermediate products for dyes.
Individual exposure to o-DCB was monitored with a passive dosimeter.
Urine samples were collected during the workshift and at the
end of the workshift. The concentrations of urinary 3,4-DCC,
4,5-DCC, 2,3-DCP and 3,4-DCP were determined with a high performance
liquid chromatograph. The mean recovery rates for urinary metabolites
obtained by our analytical method were 93.2 to 102% with coefficients
of variance of 2.7 to 7.5%. The concentrations of 3,4-DCC, 4,5-DCC,
2,3-DCP and 3,4-DCP in urine collected at the end of the workshift
and those during the last four hours of the workshift were shown
to be well correlated to the 8-hr time weighted average (8-hr
TWA) value for the exposure concentration of o-DCB. The mean
ratios (as moles) of 3,4-DCC to 4,5-DCC, that of 2,3-DCP and
that of 3,4-DCP at the end of the workshift were 0.78, 0.42 and
0.37, respectively. The time series of the concentrations of
the four metabolites showed that these concentrations varied
with time in a similar pattern. |